There are several prescription medications to treat moderate to severe acne. Many are topical (applied to the skin surface), others are taken as pills or injections. All require at least one visit to a professional dermatologist or physician. Isotretinoin (Accutane) Accutane is one of the oldest, and among the most effective, prescription medications for treating moderate to severe acne. It is used on cystic and other advanced forms and has...